We are looking for a Research Assistant or Associate (depending on experience) to join the Sanz’s laboratory at the University of Glasgow. The successful candidate will work on a BBSRC project titled: ” Why do mitochondria produce more ROS when we age? “. The project aims to understand how and why damaged mitochondria accumulate during ageing.
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Our laboratory is a leader in studying mitochondrial ROS in the context of ageing, and we have generated several fly models to manipulate the levels of mitochondrial ROS in vivo, investigating the impact of the former on lifespan. In this project, the research associate will dissect the reasons explaining the age-related accumulation of damaged mitochondria and implement new strategies to delay, prevent or stop “mitochondrial ageing”. One of the critical aspects of the project is to investigate the role of age-related epigenetic drift on mitochondrial function. The position requires the generation of Drosophila melanogaster models using state-of-the-art genome editing and the production and analysis of -omics data to dissect how mitochondria contribute to ageing. We aim to recruit enthusiastic candidates with strong knowledge of Molecular Biology. Candidates with experience culturing Drosophila, generating transgenic animal models, or bioinformatics will be given preference, but previous experience on those topics is not essential. Besides, our laboratory will provide training and mentoring to those candidates interested in applying for independent fellowships.
Relevant publications: 1. ROS signalling requires uninterrupted electron flow and is lost during ageing in flies. Geroscience. 2022 Mar 30. DOI: 10.1007/s11357-022-00555-x. 2. Mitochondrial Complex I derived ROS regulate stress adaptation in Drosophila melanogaster. Redox Biol. 2020 DOI: 10.1016/j.redox.2020.101450. 3. Mitochondrial ROS produced via reverse electron transport extends animal lifespan. Cell Metabolism 2016 DOI: 10.1016/j.cmet.2016.03.009.
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For informal inquiries about the job, please contact Prof Alberto Sanz (alberto.sanzmontero@glasgow.ac.uk).
Deadline for applications: 9th May 2022.
This post is full time with funding for 36 months.
Apply online at: https://www.jobs.ac.uk/job/CNG958/research-associate
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